RNF216 and CAPN15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RNF216	CAPN15
Description		ring finger protein 216	calpain 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission	Proteolysis
Pathways		Negative regulators of DDX58/IFIH1 signaling	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	6 interacting genes: CPEB2 DAZAP2 RNF216 SOX4 TRAF2 UBC
Entrez ID		54476	6650
HPRD ID		15550	07220
Ensembl ID		ENSG00000011275	ENSG00000103326
Uniprot IDs		A8K8N1 Q9NWF9	O75808
PDB IDs
Enriched GO Terms of Interacting Partners?
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