UBAC1 and RNF216

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UBAC1	RNF216
Description		UBA domain containing 1	ring finger protein 216
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)	Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)
Interacting Genes		36 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MGAT3 NEDD4L PLAAT2 PLEKHB2 PMPCA POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBB UBC UBQLN2 ZDHHC17 ZG16B	30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A
Entrez ID		10422	54476
HPRD ID		12170	15550
Ensembl ID		ENSG00000130560	ENSG00000011275
Uniprot IDs		A0A140VK64 Q9BSL1	A8K8N1 Q9NWF9
PDB IDs		2DAI
Enriched GO Terms of Interacting Partners?
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