PLCB2 and MAP2K6

Number of citations of the paper that reports this interaction (PubMedID 12054652)
2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PLCB2	MAP2K6
Description		phospholipase C beta 2	mitogen-activated protein kinase kinase 6
Image
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol Cytoskeleton
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatase Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Lipid Catabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste	MAPK Cascade Osteoblast Differentiation Response To Ischemia Apoptotic Process DNA Damage Induced Protein Phosphorylation Signal Transduction Response To Xenobiotic Stimulus Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Regulation Of Cell Cycle Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Bone Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)	Body shape index ( 34021172) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Eye color ( 33692100) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)
Interacting Genes		18 interacting genes: - FAM98B GCHFR GNAQ MAP2K3 MAP2K6 MTAP NEK2 PDIA3 PKD1L1 SLC9A3R1 SNCA SOCS5 SPP1 THBS1 TRIB3 TRPC3 TRPM7	39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6
Entrez ID		5330	5608
HPRD ID		04985	03155
Ensembl ID		ENSG00000137841	ENSG00000108984
Uniprot IDs		Q00722 Q59F77 Q9BVT6	A0A024R8K3 A8K3Y2 P52564
PDB IDs		2FJU 2ZKM	2Y8O 3ENM 3FME 3VN9 5ETF
Enriched GO Terms of Interacting Partners?
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