MAP2K6 and MAPK13

Number of citations of the paper that reports this interaction (PubMedID 9218798)
80

Data Source:
HPRD (in vitro)

		MAP2K6	MAPK13
Description		mitogen-activated protein kinase kinase 6	mitogen-activated protein kinase 13
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatase Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Transcription Regulator Activator Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Response To Ischemia Apoptotic Process DNA Damage Induced Protein Phosphorylation Signal Transduction Response To Xenobiotic Stimulus Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Regulation Of Cell Cycle Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Bone Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite
Pathways		NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling	NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway
Drugs		Fostamatinib	Minocycline KC706 Fostamatinib
Diseases
GWAS		Body shape index ( 34021172) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Eye color ( 33692100) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)
Interacting Genes		39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6	16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1
Entrez ID		5608	5603
HPRD ID		03155	09113
Ensembl ID		ENSG00000108984	ENSG00000156711
Uniprot IDs		A0A024R8K3 A8K3Y2 P52564	A0A024RD04 O15264
PDB IDs		2Y8O 3ENM 3FME 3VN9 5ETF	3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
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