MAP2K6 and MAP2K4

Number of citations of the paper that reports this interaction (PubMedID 15866172)
49

Data Source:
BioGRID (enzymatic study)

		MAP2K6	MAP2K4
Description		mitogen-activated protein kinase kinase 6	mitogen-activated protein kinase kinase 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatase Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Transcription Regulator Activator Activity	Protein Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Response To Ischemia Apoptotic Process DNA Damage Induced Protein Phosphorylation Signal Transduction Response To Xenobiotic Stimulus Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Regulation Of Cell Cycle Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Bone Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Fostamatinib
Diseases
GWAS		Body shape index ( 34021172) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Eye color ( 33692100) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)	Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6	44 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK7 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC
Entrez ID		5608	6416
HPRD ID		03155	03213
Ensembl ID		ENSG00000108984	ENSG00000065559
Uniprot IDs		A0A024R8K3 A8K3Y2 P52564	P45985
PDB IDs		2Y8O 3ENM 3FME 3VN9 5ETF	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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