SERPINA1 and KLK1

Number of citations of the paper that reports this interaction (PubMedID 3643793)
29

Data Source:
BioGRID (pull down)

		SERPINA1	KLK1
Description		serpin family A member 1	kallikrein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity
	Biological Process	Acute-phase Response Blood Coagulation Negative Regulation Of Endopeptidase Activity	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation
Pathways		Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33339817) Alanine transaminase levels ( 28887542) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 22808956) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 29875488 28240269 23696881) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) C-reactive protein levels ( 33227023 30388399) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Height ( 28552196 29782485) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers (total iron binding capacity) ( 33536631) Large artery stroke ( 28265093) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Manganese levels ( 26025379) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Myocardial infarction ( 33532862) Platelet count ( 27863252) Plateletcrit ( 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 31666285 33339817) Serum alpha-fetoprotein levels ( 31666285) Sucrose liking ( 31005972) Total cholesterol levels ( 30275531) Waist circumference adjusted for body mass index ( 34021172)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		31 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE FBLN5 GLP1R GSDMB HSP90AA1 KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1	8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1
Entrez ID		5265	3816
HPRD ID		02463	01003
Ensembl ID		ENSG00000197249	ENSG00000167748
Uniprot IDs		E9KL23 P01009	A0A1L2BPJ2 A0A1R3UCD2 P06870
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7API 8API 9API	1SPJ
Enriched GO Terms of Interacting Partners?
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