SERPINA1 and GSDMB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SERPINA1	GSDMB
Description		serpin family A member 1	gasdermin B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Cellular_component Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Phosphatidylserine Binding Molecular_function Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Acute-phase Response Blood Coagulation Negative Regulation Of Endopeptidase Activity	Cytolysis Defense Response To Bacterium Pyroptosis
Pathways		Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation
Drugs		Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 34315874 33339817) Alanine transaminase levels ( 28887542) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 22808956) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 29875488 28240269 23696881) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) C-reactive protein levels ( 33227023 30388399) Cirrhosis (alcohol related) ( 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Height ( 28552196 29782485) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers (total iron binding capacity) ( 33536631) Large artery stroke ( 28265093) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Manganese levels ( 26025379) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Myocardial infarction ( 33532862) Platelet count ( 27863252) Plateletcrit ( 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 31666285 33339817) Serum alpha-fetoprotein levels ( 31666285) Sucrose liking ( 31005972) Total cholesterol levels ( 30275531) Waist circumference adjusted for body mass index ( 34021172)	Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 34103634 20860503 32296059 31619474 29273806 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 27611488 24241537 29273806) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 28314753 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 21738480)
Interacting Genes		31 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE FBLN5 GLP1R GSDMB HSP90AA1 KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1	17 interacting genes: AGT APP CDK12 CLK1 CWC25 DHRS11 FNDC8 GGNBP2 HIVEP1 IGFBP2 MRM1 MYO19 NLE1 ORM1 PEBP1 SERPINA1 SLFN12
Entrez ID		5265	55876
HPRD ID		02463	17082
Ensembl ID		ENSG00000197249	ENSG00000073605
Uniprot IDs		E9KL23 P01009	Q8TAX9
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7API 8API 9API	5TIB 5TJ2 5TJ4
Enriched GO Terms of Interacting Partners?
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