KLK1 and ITIH4

Number of citations of the paper that reports this interaction (PubMedID 3643793)
29

Data Source:
BioGRID (pull down)

		KLK1	ITIH4
Description		kallikrein 1	inter-alpha-trypsin inhibitor heavy chain 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Secretory Granule Extracellular Exosome	Extracellular Region Plasma Membrane Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation	Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Platelet degranulation
Drugs		Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Blood protein levels ( 30072576) Body mass index ( 28552196 24861553) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-2) ( 22610502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Manganese levels ( 26025379) Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 28892059) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 21926974 29483656 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1	4 interacting genes: DNAJC1 GRB2 KLK1 TP63
Entrez ID		3816	3700
HPRD ID		01003	02781
Ensembl ID		ENSG00000167748	ENSG00000055955
Uniprot IDs		A0A1L2BPJ2 A0A1R3UCD2 P06870	B2RMS9 B7ZKJ8 Q14624
PDB IDs		1SPJ
Enriched GO Terms of Interacting Partners?
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