KLK1 and PROC

Number of citations of the paper that reports this interaction (PubMedID 3643793)
29

Data Source:
BioGRID (pull down)

		KLK1	PROC
Description		kallikrein 1	protein C, inactivator of coagulation factors Va and VIIIa
Image
GO Annotations	Cellular Component	Nucleus Secretory Granule Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Serine-type Endopeptidase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation	Proteolysis Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Blood protein levels ( 30072576) Protein C levels ( 28082259 25376901 20802025)
Interacting Genes		8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1	17 interacting genes: CFLAR CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 NGLY1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		3816	5624
HPRD ID		01003	01466
Ensembl ID		ENSG00000167748	ENSG00000115718
Uniprot IDs		A0A1L2BPJ2 A0A1R3UCD2 P06870	P04070
PDB IDs		1SPJ	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7 6M3B 6M3C
Enriched GO Terms of Interacting Partners?
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