PFKFB4 and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
7

Data Source:
BioGRID (enzymatic study)

		PFKFB4	PJA1
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	praja ring finger ubiquitin ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Dephosphorylation Carbohydrate Phosphorylation	Protein Ubiquitination Protein Catabolic Process
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fructose-6-phosphate
Diseases
GWAS		Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Mental health study participation (completed survey) ( 31263887) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827) Waist-hip index ( 34021172)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: CCDC102B CDC23 CSNK2B GADD45A GSK3B LRR1 PFKFB1 PJA1	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		5210	64219
HPRD ID		05613	02335
Ensembl ID		ENSG00000114268	ENSG00000181191
Uniprot IDs		B7Z5C3 Q16877 Q5XLC3 Q66S35	Q8NG27
PDB IDs			2L0B
Enriched GO Terms of Interacting Partners?
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