PJA1 and GSR

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PJA1	GSR
Description		praja ring finger ubiquitin ligase 1	glutathione-disulfide reductase
Image
GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Mitochondrial Matrix Cytosol External Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Glutathione-disulfide Reductase (NADPH) Activity Electron Transfer Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Protein Ubiquitination Protein Catabolic Process	Glutathione Metabolic Process Electron Transport Chain Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Glutathione NADH Carmustine 3,6-dihydroxy-xanthene-9-propionic acid 3-sulfino-L-alanine Glutathionylspermidine disulfide 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol Flavin adenine dinucleotide Glutathione disulfide 3-nitro-L-tyrosine 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID Cannabidiol Copper Medical Cannabis Nabiximols
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440	4 interacting genes: C11orf49 CDC42 OCM2 PJA1
Entrez ID		64219	2936
HPRD ID		02335	00704
Ensembl ID		ENSG00000181191	ENSG00000104687
Uniprot IDs		Q8NG27	P00390 V9HW90
PDB IDs		2L0B	1ALG 1BWC 1DNC 1GRA 1GRB 1GRE 1GRF 1GRG 1GRH 1GRT 1GSN 1K4Q 1XAN 2AAQ 2GH5 2GRT 3DJG 3DJJ 3DK4 3DK8 3DK9 3GRS 3GRT 3SQP 4GR1 4GRT 5GRT
Enriched GO Terms of Interacting Partners?
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