PFKFB4 and PFKFB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PFKFB4	PFKFB1
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Fructose-6-phosphate Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Dephosphorylation Carbohydrate Phosphorylation	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Dephosphorylation Animal Organ Regeneration Response To Insulin Positive Regulation Of Glucokinase Activity Response To Glucagon Response To Starvation Carbohydrate Phosphorylation Response To Glucocorticoid Response To CAMP
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	PKA-mediated phosphorylation of key metabolic factors PP2A-mediated dephosphorylation of key metabolic factors Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fructose-6-phosphate	D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-Phosphate sn-glycerol 3-phosphate Adenosine 5'-[gamma-thio]triphosphate Guanosine-5'-Triphosphate Fructose-6-phosphate
Diseases
GWAS		Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Mental health study participation (completed survey) ( 31263887) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827) Waist-hip index ( 34021172)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		8 interacting genes: CCDC102B CDC23 CSNK2B GADD45A GSK3B LRR1 PFKFB1 PJA1	15 interacting genes: AKT1 APP DDIT4L KATNBL1 PDE4A PFKFB3 PFKFB4 PLEKHG4 PRKACA PRKCA VWC2 ZNF276 ZNF474 ZNF655 ZNF688
Entrez ID		5210	5207
HPRD ID		05613	02411
Ensembl ID		ENSG00000114268	ENSG00000158571
Uniprot IDs		B7Z5C3 Q16877 Q5XLC3 Q66S35	I1Z9G4 P16118
PDB IDs			1K6M
Enriched GO Terms of Interacting Partners?
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