TMEM14C and COMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM14C	COMT
Description		transmembrane protein 14C	catechol-O-methyltransferase
Image
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane Mitochondrial Membrane	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Dendritic Spine Intracellular Membrane-bounded Organelle Cell Body Postsynaptic Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity
	Biological Process	Heme Biosynthetic Process Mitochondrial Transport Erythrocyte Differentiation Regulation Of Heme Biosynthetic Process	Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Xenobiotic Stimulus Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Response To Estrogen Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain
Pathways			Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS
Drugs			Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		46 interacting genes: ARL13B BCL2L13 BIK CLDN5 COMT COQ9 CPLANE2 CREB3 CREB3L1 CYB5R3 EBP ELOVL7 FAM209A GJB1 GORAB GPR152 HSD17B13 KASH5 LMNA LNX1 MARCHF8 MFF MMGT1 MTERF3 MUC1 NCAPH2 NCR3LG1 PDZK1IP1 PLIN3 RCHY1 SDC3 SHANK3 SLC10A6 SSMEM1 STX1A SYT1 TMEM14B TMEM31 TMEM35A TMEM52B TMEM79 TMEM86B TMX2 VSIR ZDHHC15 ZFYVE27	74 interacting genes: ACE AQP7 AVPR2 BEST2 BRS3 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HCK HIBADH HOPX HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MRPS5 MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2 ZNF43
Entrez ID		51522	1312
HPRD ID		15524	00284
Ensembl ID		ENSG00000111843	ENSG00000093010
Uniprot IDs		A0A024R001 Q9P0S9	A0A140VJG8 P21964
PDB IDs		2LOS	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?
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