COMT and EMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COMT	EMD
Description		catechol-O-methyltransferase	emerin
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendrite Dendritic Spine Intracellular Membrane-bounded Organelle Cell Body Postsynaptic Membrane Extracellular Exosome	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Cytosol Microtubule Membrane Integral Component Of Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity L-dopa O-methyltransferase Activity Orcinol O-methyltransferase Activity	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding
	Biological Process	Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Xenobiotic Stimulus Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Response To Estrogen Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain	Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Nuclear Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Blood metabolite levels ( 24816252) Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Mean spheric corpuscular volume ( 32888494)
Interacting Genes		74 interacting genes: ACE AQP7 AVPR2 BEST2 BRS3 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HCK HIBADH HOPX HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MFSD14B MRPS5 MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC7A1 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2 ZNF43	97 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L ANK1 ANKS6 AVPI1 BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CCNL2 CD33 CEP70 CERS4 CISD2 CLEC14A COMT COPS6 CPLX4 CREB3 CTNNBIP1 CXorf66 DPPA4 EFHC2 ERMAP FAM209A FATE1 GMCL1 GOLM2 GORAB GPR152 GRAMD2A HSF2BP INCA1 KASH5 KCNJ12 KCNJ18 KCNJ8 KCNN3 KIF9 KIR2DL3 LIME1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX1 MEOX2 MMGT1 MRPL45 MTERF4 MTNR1A NCAPH2 NF2 NPDC1 PAK5 PIMREG PSME1 REL RNASEH1 RNF123 SH3GL2 SH3GL3 SOWAHB SRC SSMEM1 STX1A SYNE1 TCF23 TMEM174 TMEM200A TMEM201 TMEM52B TMEM80 TMX2 TRAF3IP3 TRIM42 VAPB VAV1 YTHDC1 ZFP1 ZFP57 ZFP64 ZNF165 ZNF232 ZNF329 ZNF341 ZNF398 ZNF549 ZNF774
Entrez ID		1312	2010
HPRD ID		00284	02309
Ensembl ID		ENSG00000093010	ENSG00000102119
Uniprot IDs		A0A140VJG8 P21964	P50402
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D	1JEI 2ODC 2ODG 6GHD 6RPR
Enriched GO Terms of Interacting Partners?
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