ITIH1 and ARF4

		ITIH1	ARF4
Description		inter-alpha-trypsin inhibitor heavy chain 1	ADP ribosylation factor 4
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GO Annotations	Cellular Component	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding	GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process	Protein ADP-ribosylation Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Brain Development Learning Vesicle-mediated Transport Cell Migration Activation Of Phospholipase D Activity Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Guanosine-5'-Diphosphate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 19416921 33263727 31043756) Blood protein levels ( 29875488) Body mass index ( 25673413) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Glaucoma (primary open-angle) ( 25173105) Osteoarthritis (hip) ( 30374069) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		8 interacting genes: ARF4 ARIH2 CALR HSP90AA1 PHAX PIK3CA RBM15B SOX4	16 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 EGFR HNRNPD IKBKG ITIH1 PTEN RAB11FIP3 RCHY1 RHOA SDCBP2 SIRPA SUMO2
Entrez ID		3697	378
HPRD ID		00927	03107
Ensembl ID		ENSG00000055957	ENSG00000168374
Uniprot IDs		B7Z8B6 P19827	P18085
PDB IDs		6FPY 6FPZ	1Z6X
Enriched GO Terms of Interacting Partners?
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