ITIH1 and ARIH2

		ITIH1	ARIH2
Description		inter-alpha-trypsin inhibitor heavy chain 1	ariadne RBR E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 19416921 33263727 31043756) Blood protein levels ( 29875488) Body mass index ( 25673413) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) Glaucoma (primary open-angle) ( 25173105) Osteoarthritis (hip) ( 30374069) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: ARF4 ARIH2 CALR HSP90AA1 PHAX PIK3CA RBM15B SOX4	53 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R ITIH1 KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		3697	10425
HPRD ID		00927	09286
Ensembl ID		ENSG00000055957	ENSG00000177479
Uniprot IDs		B7Z8B6 P19827	O95376 Q53ET9 Q6IBL8
PDB IDs		6FPY 6FPZ
Enriched GO Terms of Interacting Partners?
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