GGA3 and AP1S2

Number of citations of the paper that reports this interaction (PubMedID 12215646)
93

Data Source:
HPRD (in vitro)

		GGA3	AP1S2
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 3	adaptor related protein complex 1 subunit sigma 2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Clathrin-coated Pit AP-type Membrane Coat Adaptor Complex AP-1 Adaptor Complex Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation	Intracellular Protein Transport Vesicle-mediated Transport
Pathways		TBC/RABGAPs MET receptor recycling Amyloid fiber formation	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Lung function (FEV1/FVC) ( 26635082)
Interacting Genes		38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497	5 interacting genes: AP1G1 AP1G2 GGA3 MAB21L2 TNS2
Entrez ID		23163	8905
HPRD ID		10443	04636
Ensembl ID		ENSG00000125447	ENSG00000182287
Uniprot IDs		A8K6M0 B7Z456 Q9NZ52	A0A5F9ZHW1 P56377 Q549M9
PDB IDs		1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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