RRAS2 and RIN1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid)

		RRAS2	RIN1
Description		RAS related 2	Ras and Rab interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Endocytosis Signal Transduction Regulation Of Catalytic Activity
Pathways		RND1 GTPase cycle	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	50 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CCM2 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH NRAS PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		22800	9610
HPRD ID		02518	05813
Ensembl ID		ENSG00000133818	ENSG00000174791
Uniprot IDs		P62070	A0A0S2Z4U0 Q13671
PDB IDs		2ERY
Enriched GO Terms of Interacting Partners?
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