RIN1 and TBC1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RIN1	TBC1D1
Description		Ras and Rab interactor 1	TBC1 domain family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane	Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Endocytosis Signal Transduction Regulation Of Catalytic Activity	Intracellular Protein Transport Regulation Of Protein Localization Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		RAB GEFs exchange GTP for GDP on RABs	Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		50 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CCM2 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH NRAS PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1	31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1
Entrez ID		9610	23216
HPRD ID		05813	18161
Ensembl ID		ENSG00000174791	ENSG00000065882
Uniprot IDs		A0A0S2Z4U0 Q13671	B9A6J6 Q6PJJ8 Q86TI0 Q8NC59
PDB IDs			3QYE
Enriched GO Terms of Interacting Partners?
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