RRAS2 and RASIP1

Number of citations of the paper that reports this interaction (PubMedID 15031288)
33

Data Source:
HPRD (two hybrid)

		RRAS2	RASIP1
Description		RAS related 2	Ras interacting protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		RND1 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 32888494 27863252) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2
Entrez ID		22800	54922
HPRD ID		02518	15214
Ensembl ID		ENSG00000133818	ENSG00000105538
Uniprot IDs		P62070	Q5U651 Q7L251 Q8IUR2
PDB IDs		2ERY	5KHO 5KHQ
Enriched GO Terms of Interacting Partners?
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