RRAS2 and PGGT1B

Number of citations of the paper that reports this interaction (PubMedID 15451670)
91

Data Source:
HPRD (in vitro)

		RRAS2	PGGT1B
Description		RAS related 2	protein geranylgeranyltransferase type I subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	CAAX-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Small Molecule Binding Peptide Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Positive Regulation Of Cell Population Proliferation Protein Prenylation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways		RND1 GTPase cycle
Drugs			L-778123 Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Longevity ( 30294719)
Interacting Genes		32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	6 interacting genes: CDC42 FNTA GNG2 KRAS RHOB RRAS2
Entrez ID		22800	5229
HPRD ID		02518	03612
Ensembl ID		ENSG00000133818	ENSG00000164219
Uniprot IDs		P62070	P53609
PDB IDs		2ERY
Enriched GO Terms of Interacting Partners?
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