HERPUD1 and CD58

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HERPUD1	CD58
Gene Name		homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	CD58 molecule
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Calcium Channel Complex Lewy Body Core	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Ion Channel Binding	Receptor Binding Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Adhesion Blood Coagulation Single Organismal Cell-cell Adhesion Heterotypic Cell-cell Adhesion Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Positive Regulation Of Interleukin-8 Secretion
Pathways		ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585) HDL cholesterol ( 20031564 23505323) Metabolic syndrome ( 20694148)	Multiple sclerosis ( 22190364 21244703 19525953 19525955 21833088)
Protein-Protein Interactions		16 interactors: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 STARD9 TOLLIP UBE2G2 UBQLN2 USP7 VCP XRCC6	4 interactors: APP CD2 DNAJA1 HERPUD1
Entrez ID		9709	965
HPRD ID		07456	01081
Ensembl ID		ENSG00000051108	ENSG00000116815
Uniprot IDs		A4UAE9 Q15011 Q53FP9	P19256
PDB IDs		1WGD	1CCZ 1CI5 1QA9
Enriched GO Terms of Interacting Partners?		Smooth Endoplasmic Reticulum Calcium Ion Homeostasis ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stimulus Response To Stress Double-strand Break Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Movement Of Cell Or Subcellular Component Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Differentiation Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Protein Catabolic Process Response To Stimulus DNA Repair Protein Catabolic Process Learning Or Memory Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Regulation Of Proteolysis Cellular Component Assembly Negative Regulation Of Axonogenesis Cajal-Retzius Cell Differentiation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Beta-amyloid Formation Cell Activation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cognition Negative Regulation Of Neurogenesis Neuron Death Positive Regulation Of Proteolysis Regulation Of Neurogenesis Cellular Response To Heat Positive Regulation Of Proteasomal Protein Catabolic Process Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Glycosylation Macromolecule Glycosylation Negative Regulation Of Cell Development Telomere Maintenance Regulation Of ERBB Signaling Pathway	Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Myeloid Dendritic Cell Activation Response To Unfolded Protein Negative Regulation Of Protein Metabolic Process Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Synaptic Growth At Neuromuscular Junction Cell Death Death Regulation Of Protein Phosphorylation Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Response To Stress Collateral Sprouting In Absence Of Injury Membrane Raft Polarization Locomotion Positive Regulation Of Interferon-gamma Secretion Regulation Of Phosphorylation Regulation Of Binding Negative Regulation Of Endopeptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Membrane Raft Localization Negative Regulation Of Peptidase Activity Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Myeloid Dendritic Cell Activation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Proteolysis DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Protein Processing Neuron Remodeling Positive Regulation Of Interleukin-8 Secretion Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Blood Coagulation
Tagcloud ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	amixl atl bc blast burkitt cd54 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Difference) ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	amixl atl bc blast burkitt cd54 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply
Tagcloud (Intersection) ?