CD58 and CD2

Number of citations of the paper that reports this interaction (PMID 1377404)
39

Data Source:
BioGRID (x-ray crystallography, pull down)
HPRD (in vitro)

		CD58	CD2
Gene Name		CD58 molecule	CD2 molecule
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane
	Molecular Function	Receptor Binding Protein Binding	Receptor Activity Receptor Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Adhesion Blood Coagulation Single Organismal Cell-cell Adhesion Heterotypic Cell-cell Adhesion Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Positive Regulation Of Interleukin-8 Secretion	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Blood Coagulation Single Organismal Cell-cell Adhesion Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall
Drugs			Alefacept Alpha-D-Mannose
Diseases
GWAS		Multiple sclerosis ( 22190364 21244703 19525953 19525955 21833088)
Protein-Protein Interactions		4 interactors: APP CD2 DNAJA1 HERPUD1	19 interactors: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1
Entrez ID		965	914
HPRD ID		01081	01750
Ensembl ID		ENSG00000116815	ENSG00000116824
Uniprot IDs		P19256	P06729 Q53F96
PDB IDs		1CCZ 1CI5 1QA9	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Myeloid Dendritic Cell Activation Response To Unfolded Protein Negative Regulation Of Protein Metabolic Process Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Synaptic Growth At Neuromuscular Junction Cell Death Death Regulation Of Protein Phosphorylation Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Response To Stress Collateral Sprouting In Absence Of Injury Membrane Raft Polarization Locomotion Positive Regulation Of Interferon-gamma Secretion Regulation Of Phosphorylation Regulation Of Binding Negative Regulation Of Endopeptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Membrane Raft Localization Negative Regulation Of Peptidase Activity Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Myeloid Dendritic Cell Activation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Axon Choice Point Recognition Negative Regulation Of Proteolysis DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Protein Processing Neuron Remodeling Positive Regulation Of Interleukin-8 Secretion Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Blood Coagulation	Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Immune System Process Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Defense Response To Virus Innate Immune Response Cell Migration Locomotion Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Cell Motility Signal Transduction Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Response To Wounding Signaling Lymphocyte Activation Response To Stimulus Cell Communication Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Positive Regulation Of Gamma-delta T Cell Differentiation Leukocyte Activation Leukocyte Migration Regulation Of Immune Response Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Single Organismal Cell-cell Adhesion Response To Stress Viral Process T Cell Aggregation T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Aggregation
Tagcloud ?		amixl atl bc blast burkitt cd54 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply	2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Difference) ?		amixl atl bc blast burkitt cd54 cd80 cd86 cll cml costimulatory crisis dr granular hematological hla immuno lgl lymphoblastic lymphocytic lymphoma malignancies manipulating modality myeloblastic neoplastic ph1 philadelphia sharply	2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Intersection) ?