HERPUD1 and XRCC6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		HERPUD1	XRCC6
Gene Name		homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	X-ray repair complementing defective repair in Chinese hamster cells 6
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Calcium Channel Complex Lewy Body Core	Nuclear Telomere Cap Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	Molecular_function Ion Channel Binding	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Telomere Maintenance DNA Ligation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Transcription, DNA-templated Brain Development Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding V(D)J Recombination Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neurogenesis Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways		ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)	Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585) HDL cholesterol ( 20031564 23505323) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		16 interactors: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 STARD9 TOLLIP UBE2G2 UBQLN2 USP7 VCP XRCC6	126 interactors: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 FMNL1 GAL3ST4 GSE1 GZMA GZMB H2AFX HERPUD1 HMGA2 HN1L HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11A MSX2 NAA15 NCF4 NCL NCOA6 NHP2L1 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SEP15 SERPINA2 SERPINB9 SGOL1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SPARC TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TP53 VAV1 VBP1 WBP4 WRN XRCC5 XRCC6BP1 YWHAZ ZNF512B
Entrez ID		9709	2547
HPRD ID		07456	01071
Ensembl ID		ENSG00000051108	ENSG00000196419
Uniprot IDs		A4UAE9 Q15011 Q53FP9	B1AHC8 B1AHC9 P12956
PDB IDs		1WGD	1JEQ 1JEY 1JJR 3RZX
Enriched GO Terms of Interacting Partners?		Smooth Endoplasmic Reticulum Calcium Ion Homeostasis ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stimulus Response To Stress Double-strand Break Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Movement Of Cell Or Subcellular Component Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Differentiation Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Protein Catabolic Process Response To Stimulus DNA Repair Protein Catabolic Process Learning Or Memory Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Regulation Of Proteolysis Cellular Component Assembly Negative Regulation Of Axonogenesis Cajal-Retzius Cell Differentiation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Beta-amyloid Formation Cell Activation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cognition Negative Regulation Of Neurogenesis Neuron Death Positive Regulation Of Proteolysis Regulation Of Neurogenesis Cellular Response To Heat Positive Regulation Of Proteasomal Protein Catabolic Process Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Glycosylation Macromolecule Glycosylation Negative Regulation Of Cell Development Telomere Maintenance Regulation Of ERBB Signaling Pathway	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Chromosome Organization Regulation Of Cell Death Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Cell Cycle Process Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Organic Substance Cellular Response To Stress Organelle Organization Positive Regulation Of Gene Expression Gene Expression DNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Telomere Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Mitotic Cell Cycle Embryo Development Negative Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Catalytic Activity Cellular Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Difference) ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Intersection) ?