HERPUD1 and EWSR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HERPUD1	EWSR1
Gene Name		homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	EWS RNA-binding protein 1
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Calcium Channel Complex Lewy Body Core	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	Molecular_function Ion Channel Binding	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 20838585) HDL cholesterol ( 20031564 23505323) Metabolic syndrome ( 20694148)	Breast cancer ( 23535729)
Protein-Protein Interactions		16 interactors: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 STARD9 TOLLIP UBE2G2 UBQLN2 USP7 VCP XRCC6	159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		9709	2130
HPRD ID		07456	00592
Ensembl ID		ENSG00000051108	ENSG00000182944
Uniprot IDs		A4UAE9 Q15011 Q53FP9	Q01844
PDB IDs		1WGD	2CPE
Enriched GO Terms of Interacting Partners?		Smooth Endoplasmic Reticulum Calcium Ion Homeostasis ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stimulus Response To Stress Double-strand Break Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Movement Of Cell Or Subcellular Component Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Differentiation Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Protein Catabolic Process Response To Stimulus DNA Repair Protein Catabolic Process Learning Or Memory Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Regulation Of Proteolysis Cellular Component Assembly Negative Regulation Of Axonogenesis Cajal-Retzius Cell Differentiation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Beta-amyloid Formation Cell Activation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cognition Negative Regulation Of Neurogenesis Neuron Death Positive Regulation Of Proteolysis Regulation Of Neurogenesis Cellular Response To Heat Positive Regulation Of Proteasomal Protein Catabolic Process Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Glycosylation Macromolecule Glycosylation Negative Regulation Of Cell Development Telomere Maintenance Regulation Of ERBB Signaling Pathway	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death
Tagcloud ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Difference) ?		ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Intersection) ?