SCAMP1 and SNAP25

Number of citations of the paper that reports this interaction (PMID 10777571)
25

Data Source:
BioGRID (pull down)

		SCAMP1	SNAP25
Gene Name		secretory carrier membrane protein 1	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Integral Component Of Membrane Clathrin-coated Vesicle Synaptic Vesicle Membrane Zymogen Granule Membrane Recycling Endosome Membrane	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Protein Transport	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways			Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS		Hippocampal atrophy ( 19668339)	Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		13 interactors: EGFR EPS15 FAM208B ITSN1 KRTAP13-1 SCAMP2 SLC9A7 SNAP23 SNAP25 SYNRG TP53 UBE3A ZMIZ2	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		9522	6616
HPRD ID		06072	02637
Ensembl ID		ENSG00000085365	ENSG00000132639
Uniprot IDs		O15126	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cellular Localization Synaptic Vesicle Priming Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Transport Establishment Of Protein Localization Membrane Organization Transport Protein Localization Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Negative Regulation Of ERBB Signaling Pathway Protein Transport Vesicle Fusion Cellular Response To Drug Synaptic Vesicle Exocytosis Rhythmic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Transport Establishment Of Organelle Localization Cellular Protein Complex Assembly Alkanesulfonate Metabolic Process Sperm Entry Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Positive Regulation Of Protein Kinase B Signaling Regulation Of ERBB Signaling Pathway Response To Osmotic Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Organelle Localization Regulation Of Fibroblast Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Regulation Of Circadian Rhythm Negative Regulation Of Macromitophagy Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Oligodendrocyte Apoptotic Process Astrocyte Activation Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Regulation Of Signaling Ovulation Cycle Negative Regulation Of Helicase Activity	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?		adaptins adaptor ap1 arabidopsis compartment dihydrophobic dileucine ekqtll export golgi indispensible inositol interacted localize motif prevacuolar relocation rerouted separated subcellular terminus tgn thaliana tonoplast transported transporter1 vacuolar vacuole vit1	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?		adaptins adaptor ap1 arabidopsis compartment dihydrophobic dileucine ekqtll export golgi indispensible inositol interacted localize motif prevacuolar relocation rerouted separated subcellular terminus tgn thaliana tonoplast transported transporter1 vacuolar vacuole vit1	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?