SNAP25 and KIF5B

Number of citations of the paper that reports this interaction (PMID 12475239)
11

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		SNAP25	KIF5B
Gene Name		synaptosomal-associated protein, 25kDa	kinesin family member 5B
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex	Cytoplasm Microtubule Organizing Center Kinesin Complex Microtubule Membrane Endocytic Vesicle Vesicle Ciliary Rootlet Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization	Microtubule-based Movement Cytoplasm Organization Axon Guidance Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Cellular Protein Metabolic Process Vesicle Transport Along Microtubule Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses	Peptide hormone metabolism MHC class II antigen presentation Kinesins Insulin processing Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs		Botulinum Toxin Type A
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Bipolar disorder (mood-incongruent) ( 23092984)
Protein-Protein Interactions		34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17	23 interactors: APC CDC5L DTNB GSK3B KIF5A KLC3 KTN1 NCOA2 NDRG1 PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		6616	3799
HPRD ID		02637	07214
Ensembl ID		ENSG00000132639	ENSG00000170759
Uniprot IDs		P60880	P33176 Q6P164
PDB IDs		1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR	1BG2 1MKJ 2P4N 4HNA
Enriched GO Terms of Interacting Partners?		Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion	Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Protein Localization Positive Regulation Of Apoptotic Signaling Pathway Membrane Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Protein Transport Establishment Of Protein Localization Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Development Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Apoptotic Process Mast Cell Activation Programmed Cell Death Regulation Of Intracellular Transport Intracellular Signal Transduction Cell Death Cellular Localization Death Regulation Of Apoptotic Process Intracellular Transport Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Transmission Neurogenesis Positive Regulation Of Signal Transduction Histamine Secretion By Mast Cell Signaling Regulation Of Organelle Organization Nervous System Development Cell Communication Transport Regulation Of Cellular Component Organization Synaptic Vesicle Priming Histamine Secretion
Tagcloud ?		anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?