SNAP25 and SCAMP1

Number of citations of the paper that reports this interaction (PMID 10777571)
25

Data Source:
BioGRID (pull down)

		SNAP25	SCAMP1
Gene Name		synaptosomal-associated protein, 25kDa	secretory carrier membrane protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex	Trans-Golgi Network Integral Component Of Membrane Clathrin-coated Vesicle Synaptic Vesicle Membrane Zymogen Granule Membrane Recycling Endosome Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization	Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Protein Transport
Pathways		Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs		Botulinum Toxin Type A
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17	13 interactors: EGFR EPS15 FAM208B ITSN1 KRTAP13-1 SCAMP2 SLC9A7 SNAP23 SNAP25 SYNRG TP53 UBE3A ZMIZ2
Entrez ID		6616	9522
HPRD ID		02637	06072
Ensembl ID		ENSG00000132639	ENSG00000085365
Uniprot IDs		P60880	O15126
PDB IDs		1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion	Vesicle-mediated Transport Cellular Localization Synaptic Vesicle Priming Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Vesicle Transport Establishment Of Protein Localization Membrane Organization Transport Protein Localization Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Negative Regulation Of ERBB Signaling Pathway Protein Transport Vesicle Fusion Cellular Response To Drug Synaptic Vesicle Exocytosis Rhythmic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Transport Establishment Of Organelle Localization Cellular Protein Complex Assembly Alkanesulfonate Metabolic Process Sperm Entry Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Positive Regulation Of Protein Kinase B Signaling Regulation Of ERBB Signaling Pathway Response To Osmotic Stress Positive Regulation Of Reactive Oxygen Species Metabolic Process Organelle Localization Regulation Of Fibroblast Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Regulation Of Circadian Rhythm Negative Regulation Of Macromitophagy Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Oligodendrocyte Apoptotic Process Astrocyte Activation Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Regulation Of Signaling Ovulation Cycle Negative Regulation Of Helicase Activity
Tagcloud ?		anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts	adaptins adaptor ap1 arabidopsis compartment dihydrophobic dileucine ekqtll export golgi indispensible inositol interacted localize motif prevacuolar relocation rerouted separated subcellular terminus tgn thaliana tonoplast transported transporter1 vacuolar vacuole vit1
Tagcloud (Difference) ?		anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts	adaptins adaptor ap1 arabidopsis compartment dihydrophobic dileucine ekqtll export golgi indispensible inositol interacted localize motif prevacuolar relocation rerouted separated subcellular terminus tgn thaliana tonoplast transported transporter1 vacuolar vacuole vit1
Tagcloud (Intersection) ?