NUMBL and TAB2

Number of citations of the paper that reports this interaction (PMID 18299187)
4

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NUMBL	TAB2
Gene Name		numb homolog (Drosophila)-like	TGF-beta activated kinase 1/MAP3K7 binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding K63-linked Polyubiquitin Binding
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways			Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Nuclear signaling by ERBB4 TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Kawasaki disease ( 22446962)	Breast cancer ( 22383897) Dupuytren's disease ( 21732829)
Protein-Protein Interactions		23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG	34 interactors: APP CST9L EIF2AK2 ERBB4 ESR1 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 IKBKB IKBKG IRAK1 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TRAF2 TRAF3IP1 TRAF6 UBC UBE2I VIM XIAP YWHAZ ZBTB16
Entrez ID		9253	23118
HPRD ID		04931	05483
Ensembl ID			ENSG00000055208
Uniprot IDs		Q9Y6R0	B4DIR9 Q9NYJ8
PDB IDs		3F0W	2DAE 2WWZ 2WX0 2WX1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signaling Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response Cellular Response To Organic Substance Regulation Of Innate Immune Response Cell Communication Positive Regulation Of NIK/NF-kappaB Signaling Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Defense Response Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Programmed Cell Death Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade
Tagcloud ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta	antioxidative ascertainment cat catalase ceruloplasmin cpl dependence discovered dismutase erythrocytes fig glutathione gpx gsh gssg harmful indirect linear mutual nonenzymatic oxidated peroxidase protected ref relation sod superoxide transferrin trf
Tagcloud (Difference) ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta	antioxidative ascertainment cat catalase ceruloplasmin cpl dependence discovered dismutase erythrocytes fig glutathione gpx gsh gssg harmful indirect linear mutual nonenzymatic oxidated peroxidase protected ref relation sod superoxide transferrin trf
Tagcloud (Intersection) ?