NUMBL and THPO

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NUMBL	THPO
Gene Name		numb homolog (Drosophila)-like	thrombopoietin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Extracellular Space
	Molecular Function	Protein Binding	Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis	Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development Blood Coagulation Cell Proliferation Myeloid Cell Differentiation Platelet Activation Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Kawasaki disease ( 22446962)	Platelet counts ( 22139419 20139978)
Protein-Protein Interactions		23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG	4 interactors: APH1A EP300 MPL NUMBL
Entrez ID		9253	7066
HPRD ID		04931	02500
Ensembl ID			ENSG00000090534
Uniprot IDs		Q9Y6R0	P40225 Q5FBX8
PDB IDs		3F0W	1V7M 1V7N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Cellular Response To Organic Substance Response To Organic Substance Histone H2B Acetylation Notch Signaling Pathway Cell Surface Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Apoptotic Signaling Pathway Positive Regulation By Host Of Viral Transcription Amyloid Precursor Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Cytokine-mediated Signaling Pathway Forebrain Neuroblast Division Signal Transduction Axonogenesis Membrane Protein Intracellular Domain Proteolysis Regulation Of Cytokine Production Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Signaling Axon Development Nervous System Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Lateral Ventricle Development Notch Receptor Processing Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neuron Projection Morphogenesis Somatic Stem Cell Division N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Response To Cytokine Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cell Morphogenesis Involved In Differentiation Cell Proliferation Interaction With Symbiont Membrane Protein Proteolysis Positive Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Neuron Projection Development Stem Cell Division Ventricular System Development Cell Projection Morphogenesis Organ Development
Tagcloud ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta	biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mpl mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f
Tagcloud (Difference) ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta	biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mpl mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f
Tagcloud (Intersection) ?