NUMBL and GPATCH8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NUMBL	GPATCH8
Gene Name		numb homolog (Drosophila)-like	G patch domain containing 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cellular_component
	Molecular Function	Protein Binding	Protein Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis	Biological_process
Pathways
Drugs
Diseases
GWAS		Kawasaki disease ( 22446962)
Protein-Protein Interactions		23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG	4 interactors: APH1A ATXN1 ATXN1L NUMBL
Entrez ID		9253	23131
HPRD ID		04931	11089
Ensembl ID
Uniprot IDs		Q9Y6R0	Q9UKJ3
PDB IDs		3F0W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Lung Alveolus Development Organ Development Positive Regulation Of Hematopoietic Stem Cell Proliferation Lung Development Respiratory Tube Development Neuroblast Division In Subventricular Zone Respiratory System Development System Development Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Anatomical Structure Development Amyloid Precursor Protein Catabolic Process Forebrain Neuroblast Division Axonogenesis Membrane Protein Intracellular Domain Proteolysis Developmental Process Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation Lateral Ventricle Development Notch Receptor Processing Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Somatic Stem Cell Division Tube Development Cell Morphogenesis Involved In Differentiation Membrane Protein Proteolysis Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Development Stem Cell Division Ventricular System Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Proliferation In Forebrain Neuroblast Proliferation Neuron Development Positive Regulation Of Dendrite Development Visual Learning Visual Behavior Cell Morphogenesis Regulation Of Dendrite Morphogenesis Negative Regulation Of Transcription, DNA-templated Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription Neuron Differentiation Regulation Of Postsynaptic Membrane Potential
Tagcloud ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?