TAB2 and NR2C2

Number of citations of the paper that reports this interaction (PMID 14633987)
68

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		TAB2	NR2C2
Gene Name		TGF-beta activated kinase 1/MAP3K7 binding protein 2	nuclear receptor subfamily 2, group C, member 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane	Nucleoplasm
	Molecular Function	Protein Binding Zinc Ion Binding K63-linked Polyubiquitin Binding	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Gene Expression Cerebellum Development Cell Differentiation Positive Regulation Of Embryonic Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Behavior Meiotic Cell Cycle
Pathways		Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Nuclear signaling by ERBB4 TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Breast cancer ( 22383897) Dupuytren's disease ( 21732829)	Alcohol and nictotine co-dependence ( 22488850)
Protein-Protein Interactions		34 interactors: APP CST9L EIF2AK2 ERBB4 ESR1 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 IKBKB IKBKG IRAK1 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TRAF2 TRAF3IP1 TRAF6 UBC UBE2I VIM XIAP YWHAZ ZBTB16	21 interactors: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RXRB TAB1 TAB2 TRAF2
Entrez ID		23118	7182
HPRD ID		05483	03253
Ensembl ID		ENSG00000055208
Uniprot IDs		B4DIR9 Q9NYJ8	F2YGU2 P49116 Q6PHZ7
PDB IDs		2DAE 2WWZ 2WX0 2WX1	3P0U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signaling Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response Cellular Response To Organic Substance Regulation Of Innate Immune Response Cell Communication Positive Regulation Of NIK/NF-kappaB Signaling Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Defense Response Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Programmed Cell Death Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade	Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 5 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway Response To Organic Substance Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Immune Response Regulation Of Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Immune Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway
Tagcloud ?		antioxidative ascertainment cat catalase ceruloplasmin cpl dependence discovered dismutase erythrocytes fig glutathione gpx gsh gssg harmful indirect linear mutual nonenzymatic oxidated peroxidase protected ref relation sod superoxide transferrin trf
Tagcloud (Difference) ?		antioxidative ascertainment cat catalase ceruloplasmin cpl dependence discovered dismutase erythrocytes fig glutathione gpx gsh gssg harmful indirect linear mutual nonenzymatic oxidated peroxidase protected ref relation sod superoxide transferrin trf
Tagcloud (Intersection) ?