NUMBL and EPS15

Number of citations of the paper that reports this interaction (PMID 9303539)
81

Data Source:
HPRD (in vitro, in vivo)

		NUMBL	EPS15
Gene Name		numb homolog (Drosophila)-like	epidermal growth factor receptor pathway substrate 15
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Kawasaki disease ( 22446962)	IgE grass sensitization ( 22036096)
Protein-Protein Interactions		23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG	42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1
Entrez ID		9253	2060
HPRD ID		04931	08968
Ensembl ID			ENSG00000085832
Uniprot IDs		Q9Y6R0	B1AUU8 B7Z240 H7BYP0 P42566
PDB IDs		3F0W	1C07 1EH2 1F8H 1FF1 2IV9 2JXC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome
Tagcloud ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta	6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Difference) ?		ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta	6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Intersection) ?