SOCS2 and PLA2G1B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SOCS2	PLA2G1B
Gene Name		suppressor of cytokine signaling 2	phospholipase A2, group IB (pancreas)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Cell Surface Secretory Granule
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity	Phospholipase A2 Activity Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Aging Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Glucose Transport Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Multicellular Organismal Lipid Catabolic Process Small Molecule Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylcholine Metabolic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Cytokine Signaling in Immune system Growth hormone receptor signaling	Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951 18391952) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		12 interactors: ARFIP2 BMI1 EPOR GHR IGF1R INSR PLA2G1B PRLR PTK2 RYBP SOCS3 TPD52	5 interactors: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		8835	5319
HPRD ID		05490	01396
Ensembl ID		ENSG00000120833	ENSG00000170890
Uniprot IDs		O14508	P04054
PDB IDs		2C9W 4JGH	1YSK 3ELO
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Response To Hormone Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Developmental Process Involved In Reproduction Activation Of JAK2 Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Reproductive Structure Development Peptidyl-amino Acid Modification Reproductive System Development Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Response To Organic Substance Activation Of Janus Kinase Activity Exocrine Pancreas Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process	Defense Response Dermatan Sulfate Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Amelogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of JAK-STAT Cascade Phosphatidylethanolamine Acyl-chain Remodeling Chondroitin Sulfate Biosynthetic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Growth Hormone Receptor Signaling Pathway Chondroitin Sulfate Proteoglycan Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		abrogation adenomas alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate
Tagcloud (Difference) ?		abrogation alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate
Tagcloud (Intersection) ?		adenomas