PLA2G1B

Gene Name		phospholipase A2, group IB (pancreas)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Secretory Granule
	Molecular Function	Phospholipase A2 Activity Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Glucose Transport Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Multicellular Organismal Lipid Catabolic Process Small Molecule Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylcholine Metabolic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		5319
HPRD ID		01396
Ensembl ID		ENSG00000170890
Uniprot IDs		P04054
PDB IDs		1YSK 3ELO
Enriched GO Terms of Interacting Partners?		Defense Response Dermatan Sulfate Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Amelogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of JAK-STAT Cascade Phosphatidylethanolamine Acyl-chain Remodeling Chondroitin Sulfate Biosynthetic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Growth Hormone Receptor Signaling Pathway Chondroitin Sulfate Proteoglycan Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate