SOCS2

Gene Name		suppressor of cytokine signaling 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Aging Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Cytokine Signaling in Immune system Growth hormone receptor signaling
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391951 18391952) Pubertal anthropometrics ( 23449627)
Protein-protein Interactions		12 interactors: ARFIP2 BMI1 EPOR GHR IGF1R INSR PLA2G1B PRLR PTK2 RYBP SOCS3 TPD52
Entrez ID		8835
HPRD ID		05490
Ensembl ID		ENSG00000120833
Uniprot IDs		O14508
PDB IDs		2C9W 4JGH
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Response To Hormone Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Developmental Process Involved In Reproduction Activation Of JAK2 Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Reproductive Structure Development Peptidyl-amino Acid Modification Reproductive System Development Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Response To Organic Substance Activation Of Janus Kinase Activity Exocrine Pancreas Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process
Tagcloud ?		abrogation adenomas alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel