SOCS2 and GHR

Number of citations of the paper that reports this interaction (PMID 10585430)
43

Data Source:
HPRD (in vitro, in vivo)

		SOCS2	GHR
Gene Name		suppressor of cytokine signaling 2	growth hormone receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Protein Kinase Inhibitor Activity SH3/SH2 Adaptor Activity Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity	Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Homodimerization Activity Proline-rich Region Binding
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Aging Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Activation Of MAPK Activity Allantoin Metabolic Process Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Estradiol Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Multicellular Organismal Metabolic Process Creatinine Metabolic Process Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Cytokine Signaling in Immune system Growth hormone receptor signaling	Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatropin recombinant Pegvisomant
Diseases
GWAS		Height ( 20881960 23563607 18391951 18391952) Pubertal anthropometrics ( 23449627)	Iron status biomarkers ( 19084217) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		12 interactors: ARFIP2 BMI1 EPOR GHR IGF1R INSR PLA2G1B PRLR PTK2 RYBP SOCS3 TPD52	33 interactors: AP2A1 BTRC CISH DUSP7 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 PIK3R1 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH SGTA SHC1 SOCS1 SOCS2 SOCS3 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		8835	2690
HPRD ID		05490	02971
Ensembl ID		ENSG00000120833	ENSG00000112964
Uniprot IDs		O14508	P10912
PDB IDs		2C9W 4JGH	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR
Enriched GO Terms of Interacting Partners?		Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Response To Hormone Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Developmental Process Involved In Reproduction Activation Of JAK2 Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Reproductive Structure Development Peptidyl-amino Acid Modification Reproductive System Development Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Response To Organic Substance Activation Of Janus Kinase Activity Exocrine Pancreas Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Metabolic Process	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide JAK-STAT Cascade Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Response To Organic Substance Response To Hormone Response To Organonitrogen Compound Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Regulation Of Cellular Response To Insulin Stimulus Regulation Of Signaling Response To Cytokine Regulation Of Immune System Process Regulation Of Cytokine-mediated Signaling Pathway Signaling Protein Dephosphorylation Cell Communication Peptidyl-tyrosine Dephosphorylation Regulation Of Insulin Receptor Signaling Pathway Innate Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Kinase Activity Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Immune System Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		abrogation adenomas alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Difference) ?		abrogation adenomas alcoholic ccl3 col1a2 col3a1 compromised confirming fibrotic fivefold ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs3 steatosis superarray tgfbeta threefold tolerance unravel	becomes ceptor continuous continuously cwsv dephosphorylation eliminated h7 internalization involves jak2 labile lived maintain maximal mg132 obligatory ongoing persisted pervanadate phosphotyrosine proteasome pulse requirement robust stat5b step sustaining
Tagcloud (Intersection) ?		gh ghr