PLA2G1B and PLAA

Number of citations of the paper that reports this interaction (PMID 2052621)
18

Data Source:
HPRD (in vitro)

		PLA2G1B	PLAA
Gene Name		phospholipase A2, group IB (pancreas)	phospholipase A2-activating protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Secretory Granule	Extracellular Vesicular Exosome
	Molecular Function	Phospholipase A2 Activity Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity	Protein Binding Phospholipase A2 Activator Activity
	Biological Process	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Glucose Transport Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Multicellular Organismal Lipid Catabolic Process Small Molecule Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Phosphatidylcholine Metabolic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity	Phospholipid Metabolic Process Inflammatory Response Signal Transduction Positive Regulation Of Catalytic Activity
Pathways		Acyl chain remodelling of PG Acyl chain remodelling of PE Synthesis of PA Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis Acyl chain remodelling of PC Acyl chain remodelling of PS
Drugs
Diseases
GWAS			Schizophrenia ( 20185149)
Protein-Protein Interactions		5 interactors: BGN CSF3R PLA2G2A PLAA SOCS2	6 interactors: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP
Entrez ID		5319	9373
HPRD ID		01396	04850
Ensembl ID		ENSG00000170890	ENSG00000137055
Uniprot IDs		P04054	Q9Y263
PDB IDs		1YSK 3ELO	2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?		Defense Response Dermatan Sulfate Biosynthetic Process Low-density Lipoprotein Particle Remodeling Phospholipid Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Amelogenesis Cytokine-mediated Signaling Pathway Negative Regulation Of JAK-STAT Cascade Phosphatidylethanolamine Acyl-chain Remodeling Chondroitin Sulfate Biosynthetic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Growth Hormone Receptor Signaling Pathway Chondroitin Sulfate Proteoglycan Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Growth Hormone Stimulus Cellular Response To Cytokine Stimulus Phosphatidylserine Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation	Aggresome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Protein Catabolic Process Cellular Response To Heat Intracellular Transport Proteolysis Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Hsp90 Deacetylation Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Programmed Cell Death Cellular Response To Topologically Incorrect Protein Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Response To Heat Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Localization In Cell Protein Polyubiquitination Multicellular Organismal Lipid Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Complex Assembly Response To Temperature Stimulus Interleukin-8 Production Activation Of Phospholipase A2 Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate	a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation
Tagcloud (Difference) ?		adenomas arachidonic catalyzes colorectal disequilibrium eicosanoid genotyped haplotype illumina kras linkage maf neoplasia nsaid phospholipase phospholipids polymorphisms principal rectal rs2070873 rs5637 rs9657930 ser98ser snps tagging tagsnp tagsnps trend ultimate	a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation
Tagcloud (Intersection) ?