CDKL1 and SMURF1

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		CDKL1	SMURF1
Gene Name		cyclin-dependent kinase-like 1 (CDC2-related kinase)	SMAD specific E3 ubiquitin protein ligase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding
	Biological Process	Protein Phosphorylation Heart Development Regulation Of Cell Cycle	Protein Polyubiquitination Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Protein Ubiquitination Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt TGFBR1 LBD Mutants in Cancer Signaling by BMP Hedgehog 'on' state Class I MHC mediated antigen processing & presentation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins Signaling by Hedgehog PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)	Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228798)
Protein-Protein Interactions		2 interactors: SMURF1 TGFBR1	98 interactors: ANAPC5 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASH2L AVEN AXIN1 CCM2 CDC40 CDK14 CDKL1 CSNK2A2 CUL5 CXXC1 DNAJC7 DUSP13 DVL2 ECSIT ELP3 ESR1 ETV6 FBXL15 FBXO30 FCHO1 GNG11 GRIPAP1 HDGFRP3 ING2 INPP5B IRAK2 JUNB LATS1 LHX9 LIMS1 LONRF3 MAP3K2 MAP3K3 NAA16 NDFIP2 NEDD8 OXSR1 PAK1 PAK1IP1 PDLIM7 PLEKHO1 POLR2A PSME3 PWP1 RASD2 RHOA RHPN2 RIPK2 RIT1 RNF11 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SENP8 SF3A1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPG20 SQSTM1 SRSF4 SRSF5 STK35 STRAP STUB1 TLN1 TNK2 TNNT1 TRAF4 TTC17 UBA52 UBB UBC UBE2D3 UBE2L3 UBTF UBXN1 USP45 USP9X WDR61 WEE1 WFS1 XPO1
Entrez ID		8814	57154
HPRD ID		10348	06902
Ensembl ID			ENSG00000198742
Uniprot IDs		J3KMW1 Q00532	Q9HCE7
PDB IDs		4AGU	2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Parathyroid Gland Development Endothelial Cell Activation Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Germ Cell Migration Protein Localization To Cell Surface Receptor Catabolic Process Pharyngeal System Development Response To Cholesterol Ectoderm Development Negative Regulation Of Chondrocyte Differentiation Negative Regulation Of Signal Transduction Cardiac Epithelial To Mesenchymal Transition Activin Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cartilage Development Positive Regulation Of Filopodium Assembly Protein Export From Nucleus Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Filopodium Assembly Peptidyl-threonine Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Thymus Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Collagen Fibril Organization Positive Regulation Of Endothelial Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Artery Development Tissue Development Activation Of MAPKK Activity Regulation Of Chondrocyte Differentiation	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Cellular Response To Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transferase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Phosphorylation Transcription From RNA Polymerase II Promoter Protein Catabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process DNA-templated Transcription, Initiation Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Ligase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression
Tagcloud ?			5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423
Tagcloud (Difference) ?			5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423
Tagcloud (Intersection) ?