SMURF1 and WFS1

Number of citations of the paper that reports this interaction (PMID 21454619)
6

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SMURF1	WFS1
Gene Name		SMAD specific E3 ubiquitin protein ligase 1	Wolfram syndrome 1 (wolframin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding	Transporter Activity Calmodulin Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Protein Polyubiquitination Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Protein Ubiquitination Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Kidney Development Renal Water Homeostasis ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Olfactory Behavior Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Growth Protein Stabilization Neurological System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Polyubiquitinated Misfolded Protein Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt TGFBR1 LBD Mutants in Cancer Signaling by BMP Hedgehog 'on' state Class I MHC mediated antigen processing & presentation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins Signaling by Hedgehog PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228798)	Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900)
Protein-Protein Interactions		98 interactors: ANAPC5 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASH2L AVEN AXIN1 CCM2 CDC40 CDK14 CDKL1 CSNK2A2 CUL5 CXXC1 DNAJC7 DUSP13 DVL2 ECSIT ELP3 ESR1 ETV6 FBXL15 FBXO30 FCHO1 GNG11 GRIPAP1 HDGFRP3 ING2 INPP5B IRAK2 JUNB LATS1 LHX9 LIMS1 LONRF3 MAP3K2 MAP3K3 NAA16 NDFIP2 NEDD8 OXSR1 PAK1 PAK1IP1 PDLIM7 PLEKHO1 POLR2A PSME3 PWP1 RASD2 RHOA RHPN2 RIPK2 RIT1 RNF11 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SENP8 SF3A1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPG20 SQSTM1 SRSF4 SRSF5 STK35 STRAP STUB1 TLN1 TNK2 TNNT1 TRAF4 TTC17 UBA52 UBB UBC UBE2D3 UBE2L3 UBTF UBXN1 USP45 USP9X WDR61 WEE1 WFS1 XPO1	4 interactors: EIF6 MAPK6 SMURF1 TERF1
Entrez ID		57154	7466
HPRD ID		06902	05864
Ensembl ID		ENSG00000198742	ENSG00000109501
Uniprot IDs		Q9HCE7	O76024
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Cellular Response To Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transferase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Phosphorylation Transcription From RNA Polymerase II Promoter Protein Catabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process DNA-templated Transcription, Initiation Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Ligase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression	Nuclear Export Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Nucleocytoplasmic Transport Nuclear Transport Mature Ribosome Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Ubiquitin-dependent SMAD Protein Catabolic Process Ribosomal Subunit Export From Nucleus Replicative Cell Aging Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Microtubule Polymerization Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Protein Localization To Cell Surface Receptor Catabolic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Ribosomal Large Subunit Biogenesis Ectoderm Development Ribosome Assembly Regulation Of Microtubule Polymerization Cytoplasmic Transport Telomere Maintenance Via Telomere Lengthening Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Protein Export From Nucleus Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Negative Regulation Of BMP Signaling Pathway Regulation Of DNA Biosynthetic Process Spindle Checkpoint Negative Regulation Of DNA Replication Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423	activating active atf6 atf6alpha atf6alphap50 atf6beta atf6betap60 basic consists endoplasmic er essential induce ins insulinoma islets isoforms knock maintain microarray pancreatic relates reticulum rodent stress susceptibility undergoing unfolded upr
Tagcloud (Difference) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423	activating active atf6 atf6alpha atf6alphap50 atf6beta atf6betap60 basic consists endoplasmic er essential induce ins insulinoma islets isoforms knock maintain microarray pancreatic relates reticulum rodent stress susceptibility undergoing unfolded upr
Tagcloud (Intersection) ?