SMURF1 and RIPK2

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		SMURF1	RIPK2
Gene Name		SMAD specific E3 ubiquitin protein ligase 1	receptor-interacting serine-threonine kinase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome	Cytoplasm Cytosol Cytoskeleton Vesicle Protein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding LIM Domain Binding Protein Homodimerization Activity CARD Domain Binding
	Biological Process	Protein Polyubiquitination Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Protein Ubiquitination Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Activation Of MAPK Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Inflammatory Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Response To Interleukin-1 Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide
Pathways		Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt TGFBR1 LBD Mutants in Cancer Signaling by BMP Hedgehog 'on' state Class I MHC mediated antigen processing & presentation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins Signaling by Hedgehog PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System	Downstream TCR signaling p75NTR recruits signalling complexes Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228798)	Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961)
Protein-Protein Interactions		98 interactors: ANAPC5 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASH2L AVEN AXIN1 CCM2 CDC40 CDK14 CDKL1 CSNK2A2 CUL5 CXXC1 DNAJC7 DUSP13 DVL2 ECSIT ELP3 ESR1 ETV6 FBXL15 FBXO30 FCHO1 GNG11 GRIPAP1 HDGFRP3 ING2 INPP5B IRAK2 JUNB LATS1 LHX9 LIMS1 LONRF3 MAP3K2 MAP3K3 NAA16 NDFIP2 NEDD8 OXSR1 PAK1 PAK1IP1 PDLIM7 PLEKHO1 POLR2A PSME3 PWP1 RASD2 RHOA RHPN2 RIPK2 RIT1 RNF11 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SENP8 SF3A1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPG20 SQSTM1 SRSF4 SRSF5 STK35 STRAP STUB1 TLN1 TNK2 TNNT1 TRAF4 TTC17 UBA52 UBB UBC UBE2D3 UBE2L3 UBTF UBXN1 USP45 USP9X WDR61 WEE1 WFS1 XPO1	31 interactors: BCL10 BIRC2 BIRC3 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBE2I XIAP
Entrez ID		57154	8767
HPRD ID		06902	04585
Ensembl ID		ENSG00000198742	ENSG00000104312
Uniprot IDs		Q9HCE7	O43353
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Cellular Response To Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transferase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Phosphorylation Transcription From RNA Polymerase II Promoter Protein Catabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process DNA-templated Transcription, Initiation Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Ligase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression	Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Signal Transduction Regulation Of Cell Death Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Apoptotic Process Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cytokine Production Cell Death Death Positive Regulation Of Cellular Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cytokine Production Response To Bacterium Apoptotic Process Positive Regulation Of Immune Response Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Other Organism Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Defense Response Response To Biotic Stimulus Positive Regulation Of Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Negative Regulation Of Cell Death Toll-like Receptor 2 Signaling Pathway Innate Immune Response
Tagcloud ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423	altogether appealing approved arthritis bowel conjunction crohn diagnostics drastically excessive fda gefitinib ibd ileitis improves nod1 nod2 optimization peptidoglycan peritonitis pharmaceuticals pharmacologic potently predicting productive rationale sarcoidosis sensors transduces
Tagcloud (Difference) ?		5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423	altogether appealing approved arthritis bowel conjunction crohn diagnostics drastically excessive fda gefitinib ibd ileitis improves nod1 nod2 optimization peptidoglycan peritonitis pharmaceuticals pharmacologic potently predicting productive rationale sarcoidosis sensors transduces
Tagcloud (Intersection) ?