Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
SMURF1 and RNF11
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
BioGRID
(two hybrid)
SMURF1
RNF11
Gene Name
SMAD specific E3 ubiquitin protein ligase 1
ring finger protein 11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Axon
Neuronal Cell Body
Extracellular Vesicular Exosome
Ubiquitin Ligase Complex
Nucleus
Early Endosome
Recycling Endosome
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Activin Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Biological Process
Protein Polyubiquitination
Protein Export From Nucleus
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
Negative Regulation Of Ossification
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Receptor Catabolic Process
Protein Localization To Cell Surface
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Pathways
Loss of Function of TGFBR2 in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
Downregulation of TGF-beta receptor signaling
SMAD2/3 MH2 Domain Mutants in Cancer
TGF-beta receptor signaling activates SMADs
Signaling by Wnt
TGFBR1 LBD Mutants in Cancer
Signaling by BMP
Hedgehog 'on' state
Class I MHC mediated antigen processing & presentation
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
beta-catenin independent WNT signaling
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Asymmetric localization of PCP proteins
Signaling by Hedgehog
PCP/CE pathway
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Ulcerative colitis (
20228798
)
Ventricular conduction (
21076409
)
Protein-Protein Interactions
98 interactors:
ANAPC5
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASH2L
AVEN
AXIN1
CCM2
CDC40
CDK14
CDKL1
CSNK2A2
CUL5
CXXC1
DNAJC7
DUSP13
DVL2
ECSIT
ELP3
ESR1
ETV6
FBXL15
FBXO30
FCHO1
GNG11
GRIPAP1
HDGFRP3
ING2
INPP5B
IRAK2
JUNB
LATS1
LHX9
LIMS1
LONRF3
MAP3K2
MAP3K3
NAA16
NDFIP2
NEDD8
OXSR1
PAK1
PAK1IP1
PDLIM7
PLEKHO1
POLR2A
PSME3
PWP1
RASD2
RHOA
RHPN2
RIPK2
RIT1
RNF11
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SENP8
SF3A1
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SPG20
SQSTM1
SRSF4
SRSF5
STK35
STRAP
STUB1
TLN1
TNK2
TNNT1
TRAF4
TTC17
UBA52
UBB
UBC
UBE2D3
UBE2L3
UBTF
UBXN1
USP45
USP9X
WDR61
WEE1
WFS1
XPO1
68 interactors:
AKT1
ANKRD13A
APP
ASCC2
AUP1
CALCOCO2
CBLB
CCDC127
DCUN1D1
EPN1
EPN2
EPN3
EPS15
ERCC6
GGA1
GGA2
GGA3
HERC1
HERC2
HUWE1
IKBKG
ITCH
MYO6
NEDD4
NEDD4L
OPTN
PDCD6IP
POLI
PTPRC
QARS
RABGEF1
RIPK1
RNF168
RNF216
RPS27A
SDCBP
SMURF1
SMURF2
SNRNP70
SPRTN
STAM2
STAMBP
STAMBPL1
TAX1BP1
TNFAIP3
TNIP1
TOM1L2
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBQLN2
UBQLN4
USP5
WWP1
WWP2
ZFYVE16
ZFYVE9
ZNF350
Entrez ID
57154
26994
HPRD ID
06902
09955
Ensembl ID
ENSG00000198742
ENSG00000123091
Uniprot IDs
Q9HCE7
Q9Y3C5
PDB IDs
2LAZ
2LB0
2LB1
2LTX
3PYC
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Signal Transduction
Cellular Protein Modification Process
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Positive Regulation Of Cellular Protein Metabolic Process
Signal Transduction
Regulation Of Protein Ubiquitination
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Cellular Response To Organic Substance
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Cellular Protein Metabolic Process
Regulation Of Signal Transduction
Signaling
Positive Regulation Of Metabolic Process
Cell Communication
Cellular Response To Stimulus
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transferase Activity
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Signaling
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Protein Phosphorylation
Transcription From RNA Polymerase II Promoter
Protein Catabolic Process
Regulation Of Cellular Process
Transcription Initiation From RNA Polymerase II Promoter
Proteolysis Involved In Cellular Protein Catabolic Process
DNA-templated Transcription, Initiation
Cellular Protein Catabolic Process
Response To Organic Substance
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Metabolic Process
Positive Regulation Of Ligase Activity
Response To Stimulus
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Gene Expression
Protein Ubiquitination
Protein Polyubiquitination
Protein Modification By Small Protein Conjugation
Protein Catabolic Process
Cellular Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Positive Regulation Of Protein Catabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Proteolysis
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Innate Immune Response
Regulation Of Protein Catabolic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Protein Modification Process
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Negative Regulation Of Signaling
Toll-like Receptor 4 Signaling Pathway
Protein K63-linked Ubiquitination
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Cellular Protein Metabolic Process
Proteasomal Protein Catabolic Process
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Type I Interferon Production
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Immune Response-regulating Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Intracellular Transport
Cellular Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Metabolic Process
Intracellular Protein Transport
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Innate Immune Response
Cellular Response To Stimulus
Tagcloud
?
5p
acvr2a
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
mapk3
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
systematically
tgfbr3
zfp423
Tagcloud (Difference)
?
5p
acvr2a
alters
applying
bmp
bmp1a
cleaves
cluster
copyright
dies1
furin
impairs
interferes
mapk3
micrornas
mineralization
mir
osteoblast
osteoblasts
protected
reprogramming
reserved
rights
ski
smad
smad5
systematically
tgfbr3
zfp423
Tagcloud (Intersection)
?