EIF3I and TGFBR2

Number of citations of the paper that reports this interaction (PMID 7566156)
26

Data Source:
HPRD (in vivo, in vitro)

		EIF3I	TGFBR2
Gene Name		eukaryotic translation initiation factor 3, subunit I	transforming growth factor, beta receptor II (70/80kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Glycerol
Diseases
GWAS			Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM	44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		8668	7048
HPRD ID		04884	01823
Ensembl ID		ENSG00000084623	ENSG00000163513
Uniprot IDs		Q13347 Q5U0F4	A3QNQ0 D2JYI1 P37173
PDB IDs			1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis
Tagcloud ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Intersection) ?