EIF3I and HARS

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		EIF3I	HARS
Gene Name		eukaryotic translation initiation factor 3, subunit I	histidyl-tRNA synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm Cytosol
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Histidine-tRNA Ligase Activity ATP Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Gene Expression
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs			L-Histidine
Diseases
GWAS
Protein-Protein Interactions		34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM	6 interactors: EEF1B2 EEF1G EIF3I RPL5 TARS TNIK
Entrez ID		8668	3035
HPRD ID		04884	00827
Ensembl ID		ENSG00000084623	ENSG00000170445
Uniprot IDs		Q13347 Q5U0F4	B3KWE1 B4DDD8 B4E1C5 P12081
PDB IDs			1X59 2LW7 4G84 4G85
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated	Translation Translational Elongation Cellular Protein Metabolic Process Protein Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Threonyl-tRNA Aminoacylation Translational Initiation Biosynthetic Process Activation Of JNKK Activity Ribonucleoprotein Complex Biogenesis Protein Localization To Membrane Microvillus Assembly Microvillus Organization
Tagcloud ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	ascertain botulinum cgi clinician compulsive dysphonia ghq hamilton hdrs impression obsessive pathologist psychometrics psychoticism ql rated rating reevaluated sds somatization somatoform spasmodic speech subscales toxin unilaterally vocal voice zung
Tagcloud (Difference) ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	ascertain botulinum cgi clinician compulsive dysphonia ghq hamilton hdrs impression obsessive pathologist psychometrics psychoticism ql rated rating reevaluated sds somatization somatoform spasmodic speech subscales toxin unilaterally vocal voice zung
Tagcloud (Intersection) ?