EIF3I and RORC

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		EIF3I	RORC
Gene Name		eukaryotic translation initiation factor 3, subunit I	RAR-related orphan receptor C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Nucleoplasm
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Xenobiotic Metabolic Process Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression T Cell Differentiation In Thymus Cellular Response To Sterol T-helper Cell Differentiation Positive Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Lymph Node Development Peyer's Patch Development Adipose Tissue Development Regulation Of Transcription Involved In Cell Fate Commitment Negative Regulation Of Thymocyte Apoptotic Process T-helper 17 Cell Differentiation
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM	5 interactors: CHD4 EIF3I EIF4EBP1 EVI2A NCOA6
Entrez ID		8668	6097
HPRD ID		04884	04250
Ensembl ID		ENSG00000084623	ENSG00000143365
Uniprot IDs		Q13347 Q5U0F4	B6ZGS6 F1D8P6 H7BYJ4 P51449 Q6I9R9
PDB IDs			3B0W 3KYT 3L0J 3L0L
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated	Regulation Of Translational Initiation Translational Initiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Translation Glucocorticoid Receptor Signaling Pathway Gene Expression Cytoplasmic Translational Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex TOR Signaling Labyrinthine Layer Blood Vessel Development Response To Ischemia Biosynthetic Process Translation Regulation Of Gene Expression
Tagcloud ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3
Tagcloud (Difference) ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3
Tagcloud (Intersection) ?