EIF3I and LAMB1

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		EIF3I	LAMB1
Gene Name		eukaryotic translation initiation factor 3, subunit I	laminin, beta 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-2 Complex Extracellular Space Extracellular Matrix Laminin-8 Complex Laminin-10 Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Enzyme Binding Glycosphingolipid Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Embryo Implantation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Odontogenesis Positive Regulation Of Epithelial Cell Proliferation
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			IgG glycosylation ( 23382691) Ulcerative colitis ( 19915572 20228799 19122664)
Protein-Protein Interactions		34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM	10 interactors: ACHE ANTXR2 ATXN7 ATXN7L2 CACNA1A COL6A1 EIF3I ERBB2IP GFI1B TGFB1
Entrez ID		8668	3912
HPRD ID		04884	01029
Ensembl ID		ENSG00000084623	ENSG00000091136
Uniprot IDs		Q13347 Q5U0F4	P07942 Q8TAS6
PDB IDs
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated	Cell Growth Neurotransmitter Metabolic Process Ossification Cellular Component Assembly Regulation Of Protein Secretion Cerebellar Molecular Layer Development Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Receptor Biosynthetic Process Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Synapse Assembly Receptor Metabolic Process Endoderm Development Cell Adhesion Growth Acetylcholine Catabolic Process Vestibular Nucleus Development Basal Protein Localization Active Induction Of Host Immune Response By Virus Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Histone Modification Negative Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Neurotransmitter Levels Osteoblast Differentiation Regulation Of Protein Transport Regulation Of Secretion Negative Regulation Of Macrophage Cytokine Production Ossification Involved In Bone Remodeling Tolerance Induction To Self Antigen Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Exit From Mitosis Gamma-aminobutyric Acid Secretion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization ERBB Signaling Pathway Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Receptor Biosynthetic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Frontal Suture Morphogenesis Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Acetylcholine Secretion, Neurotransmission Synapse Organization Cell Morphogenesis Involved In Differentiation
Tagcloud ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	acad amp analogs boylan chambon cyclic dhss dhss2 dnase electrophoretic endoderm enhancer f9 flanking gudas homeobox hypersensitive laminin lohnes maximally natl parietal proc ra taneja teratocarcinoma transcriptionally transfections ttattaaca
Tagcloud (Difference) ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized	acad amp analogs boylan chambon cyclic dhss dhss2 dnase electrophoretic endoderm enhancer f9 flanking gudas homeobox hypersensitive laminin lohnes maximally natl parietal proc ra taneja teratocarcinoma transcriptionally transfections ttattaaca
Tagcloud (Intersection) ?