SCIN and ACTC1

Number of citations of the paper that reports this interaction (PMID 12438125)
1

Data Source:
HPRD (in vivo)

		SCIN	ACTC1
Gene Name		scinderin	actin, alpha, cardiac muscle 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell Cortex Protein Complex Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Phosphatidylserine Binding Actin Binding Calcium Ion Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Negative Regulation Of Cell Proliferation Calcium Ion-dependent Exocytosis Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Positive Regulation Of Secretion Actin Filament Capping	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		3 interactors: ACTA1 ACTC1 ACTG1	35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1
Entrez ID		85477	70
HPRD ID		11539	00015
Ensembl ID		ENSG00000006747	ENSG00000159251
Uniprot IDs		Q9Y6U3	B3KPP5 P68032
PDB IDs		3FG6
Enriched GO Terms of Interacting Partners?		Myofibril Assembly Actomyosin Structure Organization Skeletal Muscle Thin Filament Assembly Striated Muscle Cell Development Skeletal Myofibril Assembly Muscle Cell Development Striated Muscle Cell Differentiation Muscle Cell Differentiation Muscle Filament Sliding Actin-myosin Filament Sliding Organelle Assembly Actin-mediated Cell Contraction Muscle Structure Development Actin Cytoskeleton Organization Actin Filament-based Movement Actin Filament-based Process Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Skeletal Muscle Fiber Adaptation Muscle Contraction Movement Of Cell Or Subcellular Component Muscle System Process Muscle Organ Development Cell Development Actin Filament Organization Striated Muscle Tissue Development Cellular Component Assembly Muscle Tissue Development Anatomical Structure Morphogenesis Skeletal Muscle Adaptation Organelle Organization Cardiac Myofibril Assembly Skeletal Muscle Fiber Development Cell Differentiation Myotube Cell Development Response To Lithium Ion Platelet Aggregation System Development Muscle Fiber Development Sarcomere Organization Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Myotube Differentiation Retina Homeostasis Muscle Tissue Morphogenesis Multicellular Organismal Development Heart Contraction Cardiac Muscle Cell Development Muscle Organ Morphogenesis Anatomical Structure Development	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly
Tagcloud ?		a549 actin advantage arrest b1 capping carcinoma colony cytometry depletion excess g0 g1 h1299 homologue interference knockdown lentivirus lung p21 parp rnai scinderin severing silencing sub took yet zebrafish	accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?		a549 actin advantage arrest b1 capping carcinoma colony cytometry depletion excess g0 g1 h1299 homologue interference knockdown lentivirus lung p21 parp rnai scinderin severing silencing sub took yet zebrafish	accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?