MAP4K3 and SORBS1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		MAP4K3	SORBS1
Gene Name		mitogen-activated protein kinase kinase kinase kinase 3	sorbin and SH3 domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction Regulation Of Catalytic Activity	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: BIN1 COPS5 GRB2 ITSN2 SH3GL2 SH3RF1 SORBS1	25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL
Entrez ID		8491	10580
HPRD ID		05373	05587
Ensembl ID		ENSG00000011566	ENSG00000095637
Uniprot IDs		A8K602 B3KMM5 Q8IVH8	Q9BX66
PDB IDs			2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Regulation Of Signal Transduction Endocytosis Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Metabolic Process Transport Regulation Of MAPK Cascade Lipid Tube Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of JNK Cascade ERBB Signaling Pathway Positive Regulation Of Metabolic Process Exosomal Secretion Regulation Of Stress-activated MAPK Cascade Regulation Of Endocytosis Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Cullin Deneddylation Negative Regulation Of Signal Transduction Positive Regulation Of Astrocyte Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Response To Insulin Protein Deneddylation Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Glycogen Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Vesicle-mediated Transport Protein-lipid Complex Assembly Axon Guidance Labyrinthine Layer Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Response To Peptide Hormone Cellular Response To Organonitrogen Compound Positive Regulation Of Protein Localization To Plasma Membrane Generation Of Neurons	Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Tagcloud ?		candidates drosophila hepg2 highlight hippo mammals mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk stk25 stk39 stradalpha talk tao2 taz tead1 yap1	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Difference) ?		candidates drosophila hepg2 highlight hippo mammals mcf7 mediating modulators mst mst1 mst3 mtor mtorc1 pak1 rapamycin salvador slk sought sterile stk stk25 stk39 stradalpha talk tao2 taz tead1 yap1	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Intersection) ?