TMC5 and NUMBL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TMC5	NUMBL
Gene Name		transmembrane channel-like 5	numb homolog (Drosophila)-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function		Protein Binding
	Biological Process	Ion Transport	Nervous System Development Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis
Pathways
Drugs
Diseases
GWAS		Sleep duration ( 23728906)	Kawasaki disease ( 22446962)
Protein-Protein Interactions		1 interactors: NUMBL	23 interactors: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 YWHAG
Entrez ID		79838	9253
HPRD ID		15516	04931
Ensembl ID		ENSG00000103534
Uniprot IDs		B7Z946 F5GYU8 H3BN68 Q6UXY8	Q9Y6R0
PDB IDs			3F0W
Enriched GO Terms of Interacting Partners?		Neuroblast Division In Subventricular Zone Forebrain Neuroblast Division Lateral Ventricle Development Somatic Stem Cell Division Positive Regulation Of Dendrite Morphogenesis Stem Cell Division Ventricular System Development Cell Proliferation In Forebrain Neuroblast Proliferation Positive Regulation Of Dendrite Development Regulation Of Dendrite Morphogenesis Forebrain Generation Of Neurons Adherens Junction Organization Stem Cell Proliferation Regulation Of Dendrite Development Neural Precursor Cell Proliferation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Projection Organization Telencephalon Development Positive Regulation Of Neuron Differentiation	Positive Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Kinase Activity Regulation Of MAP Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Regulation Of MAPK Cascade Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cell Communication MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?			ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Difference) ?			ablation abrogated accordingly corrected defective deletion derepression elucidated entire forced ikk2 integrating jkappa mechanistically modulator nicd notch oncogenesis osteoclastogenesis osteopetrosis pathologic physiologic rbpj repertoire rescue restored tak1 tgfbeta
Tagcloud (Intersection) ?