TRH and CPE

Number of citations of the paper that reports this interaction (PMID 12270926)
13

Data Source:
HPRD (in vivo)

		TRH	CPE
Gene Name		thyrotropin-releasing hormone	carboxypeptidase E
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Plasma Membrane Secretory Granule	Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Neuropeptide Hormone Activity Thyrotropin-releasing Hormone Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Response To Hypoxia Histamine Metabolic Process Signal Transduction Cell-cell Signaling Adult Walking Behavior Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Proteolysis Neuropeptide Signaling Pathway Metabolic Process Insulin Processing Cellular Protein Metabolic Process Protein Localization To Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Peptide hormone metabolism Insulin processing
Drugs			Insulin Regular Insulin, porcine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ARRB2 CPE TRHR	17 interactors: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Entrez ID		7200	1363
HPRD ID		08944	00272
Ensembl ID		ENSG00000170893	ENSG00000109472
Uniprot IDs		P20396	P16870
PDB IDs
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Follicle-stimulating Hormone Signaling Pathway Insulin Processing Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Synaptic Transmission, Dopaminergic Insulin Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process G-protein Coupled Receptor Internalization Negative Regulation Of Interleukin-1 Beta Production Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cardiac Left Ventricle Morphogenesis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Synaptic Transmission, Dopaminergic Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Positive Regulation Of DNA Biosynthetic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-12 Production Regulation Of Androgen Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Toll-like Receptor Signaling Pathway Detection Of Temperature Stimulus Regulation Of Receptor Internalization Sensory Perception Of Temperature Stimulus Negative Regulation Of Mitochondrion Organization Negative Regulation Of GTPase Activity Peptide Hormone Processing Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Innate Immune Response Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Receptor Internalization Regulation Of DNA Biosynthetic Process Adult Walking Behavior Regulation Of Interleukin-1 Beta Production Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Protein Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Interleukin-12 Production Negative Regulation Of NF-kappaB Transcription Factor Activity Ovarian Follicle Development Cardiac Ventricle Morphogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Kinase B Signaling	Feeding Behavior Negative Regulation Of Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Behavior Regulation Of Feeding Behavior Positive Regulation Of Hormone Secretion Telomere Maintenance Via Semi-conservative Replication G-protein Coupled Receptor Signaling Pathway Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Oligomerization Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Eating Behavior DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Glucose Metabolic Process Regulation Of Behavior Behavioral Fear Response Neuron Recognition Positive Regulation Of Protein Secretion Regulation Of Cellular Ketone Metabolic Process Regulation Of Insulin Secretion Fear Response Response To Hormone Regulation Of Peptide Hormone Secretion Regulation Of Gluconeogenesis Cellular Response To Hormone Stimulus Response To Anesthetic Response To Fluoxetine Response To L-glutamate Regulation Of Hormone Secretion Regulation Of Synapse Assembly Positive Regulation Of Insulin Secretion Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Positive Regulation Of Secretion Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Negative Chemotaxis Positive Regulation Of Protein Transport Multicellular Organismal Response To Stress Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Taste Bud Development Apoptotic Process Involved In Luteolysis Dendrite Extension
Tagcloud ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon	attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion
Tagcloud (Difference) ?		atrophy brainstem cerebellar cerebellum computed cortex disturbance flows frontal ganglia infusion intravenous latency lobe matter olivopontocerebellar opca outside prolongation recorder regional releasing subclinical synax thalamus thyrotropin tomography white xenon	attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion
Tagcloud (Intersection) ?